Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization
Identifieur interne : 000B87 ( Main/Exploration ); précédent : 000B86; suivant : 000B88Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization
Auteurs : Ludvic Zrinzo [Suède, Royaume-Uni] ; Laurence V. Zrinzo [Suède, Royaume-Uni] ; Stephen Tisch [Suède, Royaume-Uni] ; Patricia Dowsey Limousin [Suède, Royaume-Uni] ; Tarek A. Yousry [Suède, Royaume-Uni] ; Farhad Afshar [Suède, Royaume-Uni] ; Marwan I. Hariz [Suède, Royaume-Uni]Source :
- Brain [ 0006-8950 ] ; 2008-06.
Abstract
The pedunculopontine nucleus (PPN) is a promising new target for deep brain stimulation (DBS) in parkinsonian patients with gait disturbance and postural instability refractory to other treatment modalities. This region of the brain is unfamiliar territory to most functional neurosurgeons. This paper reviews the anatomy of the human PPN and describes novel, clinically relevant methods for the atlas-based and MRI-based localization of the nucleus. These two methods of PPN localization are evaluated and compared on stereotactic MRI data acquired from a diverse group of 12 patients undergoing implantation of deep brain electrodes at sites other than the PPN. Atlas-based coordinates of the rostral and caudal PPN poles in relation to fourth ventricular landmarks were established by amalgamating information sourced from two published human brain atlases. These landmarks were identified on acquired T1 images and atlas-derived coordinates used to plot the predicted PPN location on all 24 sides. Images acquired using a specifically modified, proton-density MRI protocol were available for each patient and were spatially fused to the T1 images. This widely available and rapid protocol provided excellent definition between gray and white matter within the region of interest. Together with an understanding of the regional anatomy, direct localization of the PPN was possible on all 24 sides. The coordinates for each directly localized nucleus were measured in relation to third and fourth ventricular landmarks. The mean (SD) of the directly localized PPN midpoints was 6.4 mm (0.5) lateral, 3.5 mm (1.0) posterior and 11.4 mm (1.2) caudal to the posterior commissure in the anterior commissure–posterior commissure plane. For the directly localized nucleus, there was similar concordance for the rostral pole of the PPN in relation to third and fourth ventricular landmarks (P>0.05). For the caudal PPN pole, fourth ventricular landmarks provided greater concordance with reference to the anteroposterior coordinate (P<0.001). There was a significant difference between localization of the PPN poles as predicted by atlas-based coordinates and direct MRI localization. This difference affected mainly the rostrocaudal coordinates; the mean lateral and anteroposterior coordinates of the directly localized PPN poles were within 0.5 mm of the atlas-based predicted values. Our findings provide simple, rapid and precise methods that are of clinical relevance to the atlas-based and direct stereotactic localization of the human PPN. Direct MRI localization may allow greater individual accuracy than that afforded by atlas-based coordinates when localizing the human PPN and may be relevant to groups evaluating the clinical role of PPN DBS.
Url:
DOI: 10.1093/brain/awn075
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization</title><author><name sortKey="Zrinzo, Ludvic" sort="Zrinzo, Ludvic" uniqKey="Zrinzo L" first="Ludvic" last="Zrinzo">Ludvic Zrinzo</name></author><author><name sortKey="Zrinzo, Laurence V" sort="Zrinzo, Laurence V" uniqKey="Zrinzo L" first="Laurence V." last="Zrinzo">Laurence V. Zrinzo</name></author><author><name sortKey="Tisch, Stephen" sort="Tisch, Stephen" uniqKey="Tisch S" first="Stephen" last="Tisch">Stephen Tisch</name></author><author><name sortKey="Limousin, Patricia Dowsey" sort="Limousin, Patricia Dowsey" uniqKey="Limousin P" first="Patricia Dowsey" last="Limousin">Patricia Dowsey Limousin</name></author><author><name sortKey="Yousry, Tarek A" sort="Yousry, Tarek A" uniqKey="Yousry T" first="Tarek A." last="Yousry">Tarek A. Yousry</name></author><author><name sortKey="Afshar, Farhad" sort="Afshar, Farhad" uniqKey="Afshar F" first="Farhad" last="Afshar">Farhad Afshar</name></author><author><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:464220914CF1D24BAA9D72BF263683114786B324</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1093/brain/awn075</idno><idno type="url">https://api.istex.fr/document/464220914CF1D24BAA9D72BF263683114786B324/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002909</idno><idno type="wicri:Area/Main/Curation">002559</idno><idno type="wicri:Area/Main/Exploration">000B87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization</title><author><name sortKey="Zrinzo, Ludvic" sort="Zrinzo, Ludvic" uniqKey="Zrinzo L" first="Ludvic" last="Zrinzo">Ludvic Zrinzo</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Unit of Functional Neurosurgery, Institute of Neurology, University College London, Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK, Department of Anatomy, Genetics and Cell Biology, University of Malta, Msida, MSD.2080, Malta, Lysholm Department of Radiology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK Department of Neurosurgery, Barts and The London Centre for Neurosciences, The Royal London Hospital, Whitechapel Road, Whitechapel, London E1 1BB, UK and Department of Neurosurgery, University Hospital, Umeå 90815</wicri:regionArea><wicri:noRegion>Umeå 90815</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Correspondence to: Ludvic Zrinzo, Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Zrinzo, Laurence V" sort="Zrinzo, Laurence V" uniqKey="Zrinzo L" first="Laurence V." last="Zrinzo">Laurence V. Zrinzo</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Unit of Functional Neurosurgery, Institute of Neurology, University College London, Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK, Department of Anatomy, Genetics and Cell Biology, University of Malta, Msida, MSD.2080, Malta, Lysholm Department of Radiology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK Department of Neurosurgery, Barts and The London Centre for Neurosciences, The Royal London Hospital, Whitechapel Road, Whitechapel, London E1 1BB, UK and Department of Neurosurgery, University Hospital, Umeå 90815</wicri:regionArea><wicri:noRegion>Umeå 90815</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Correspondence to: Ludvic Zrinzo, Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Tisch, Stephen" sort="Tisch, Stephen" uniqKey="Tisch S" first="Stephen" last="Tisch">Stephen Tisch</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Unit of Functional Neurosurgery, Institute of Neurology, University College London, Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK, Department of Anatomy, Genetics and Cell Biology, University of Malta, Msida, MSD.2080, Malta, Lysholm Department of Radiology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK Department of Neurosurgery, Barts and The London Centre for Neurosciences, The Royal London Hospital, Whitechapel Road, Whitechapel, London E1 1BB, UK and Department of Neurosurgery, University Hospital, Umeå 90815</wicri:regionArea><wicri:noRegion>Umeå 90815</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Correspondence to: Ludvic Zrinzo, Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Limousin, Patricia Dowsey" sort="Limousin, Patricia Dowsey" uniqKey="Limousin P" first="Patricia Dowsey" last="Limousin">Patricia Dowsey Limousin</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Unit of Functional Neurosurgery, Institute of Neurology, University College London, Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK, Department of Anatomy, Genetics and Cell Biology, University of Malta, Msida, MSD.2080, Malta, Lysholm Department of Radiology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK Department of Neurosurgery, Barts and The London Centre for Neurosciences, The Royal London Hospital, Whitechapel Road, Whitechapel, London E1 1BB, UK and Department of Neurosurgery, University Hospital, Umeå 90815</wicri:regionArea><wicri:noRegion>Umeå 90815</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Correspondence to: Ludvic Zrinzo, Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Yousry, Tarek A" sort="Yousry, Tarek A" uniqKey="Yousry T" first="Tarek A." last="Yousry">Tarek A. Yousry</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Unit of Functional Neurosurgery, Institute of Neurology, University College London, Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK, Department of Anatomy, Genetics and Cell Biology, University of Malta, Msida, MSD.2080, Malta, Lysholm Department of Radiology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK Department of Neurosurgery, Barts and The London Centre for Neurosciences, The Royal London Hospital, Whitechapel Road, Whitechapel, London E1 1BB, UK and Department of Neurosurgery, University Hospital, Umeå 90815</wicri:regionArea><wicri:noRegion>Umeå 90815</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Correspondence to: Ludvic Zrinzo, Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Afshar, Farhad" sort="Afshar, Farhad" uniqKey="Afshar F" first="Farhad" last="Afshar">Farhad Afshar</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Unit of Functional Neurosurgery, Institute of Neurology, University College London, Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK, Department of Anatomy, Genetics and Cell Biology, University of Malta, Msida, MSD.2080, Malta, Lysholm Department of Radiology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK Department of Neurosurgery, Barts and The London Centre for Neurosciences, The Royal London Hospital, Whitechapel Road, Whitechapel, London E1 1BB, UK and Department of Neurosurgery, University Hospital, Umeå 90815</wicri:regionArea><wicri:noRegion>Umeå 90815</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Correspondence to: Ludvic Zrinzo, Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Unit of Functional Neurosurgery, Institute of Neurology, University College London, Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK, Department of Anatomy, Genetics and Cell Biology, University of Malta, Msida, MSD.2080, Malta, Lysholm Department of Radiology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK Department of Neurosurgery, Barts and The London Centre for Neurosciences, The Royal London Hospital, Whitechapel Road, Whitechapel, London E1 1BB, UK and Department of Neurosurgery, University Hospital, Umeå 90815</wicri:regionArea><wicri:noRegion>Umeå 90815</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Correspondence to: Ludvic Zrinzo, Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-06">2008-06</date><biblScope unit="volume">131</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1588">1588</biblScope><biblScope unit="page" to="1598">1598</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">464220914CF1D24BAA9D72BF263683114786B324</idno><idno type="DOI">10.1093/brain/awn075</idno><idno type="ArticleID">awn075</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The pedunculopontine nucleus (PPN) is a promising new target for deep brain stimulation (DBS) in parkinsonian patients with gait disturbance and postural instability refractory to other treatment modalities. This region of the brain is unfamiliar territory to most functional neurosurgeons. This paper reviews the anatomy of the human PPN and describes novel, clinically relevant methods for the atlas-based and MRI-based localization of the nucleus. These two methods of PPN localization are evaluated and compared on stereotactic MRI data acquired from a diverse group of 12 patients undergoing implantation of deep brain electrodes at sites other than the PPN. Atlas-based coordinates of the rostral and caudal PPN poles in relation to fourth ventricular landmarks were established by amalgamating information sourced from two published human brain atlases. These landmarks were identified on acquired T1 images and atlas-derived coordinates used to plot the predicted PPN location on all 24 sides. Images acquired using a specifically modified, proton-density MRI protocol were available for each patient and were spatially fused to the T1 images. This widely available and rapid protocol provided excellent definition between gray and white matter within the region of interest. Together with an understanding of the regional anatomy, direct localization of the PPN was possible on all 24 sides. The coordinates for each directly localized nucleus were measured in relation to third and fourth ventricular landmarks. The mean (SD) of the directly localized PPN midpoints was 6.4 mm (0.5) lateral, 3.5 mm (1.0) posterior and 11.4 mm (1.2) caudal to the posterior commissure in the anterior commissure–posterior commissure plane. For the directly localized nucleus, there was similar concordance for the rostral pole of the PPN in relation to third and fourth ventricular landmarks (P>0.05). For the caudal PPN pole, fourth ventricular landmarks provided greater concordance with reference to the anteroposterior coordinate (P<0.001). There was a significant difference between localization of the PPN poles as predicted by atlas-based coordinates and direct MRI localization. This difference affected mainly the rostrocaudal coordinates; the mean lateral and anteroposterior coordinates of the directly localized PPN poles were within 0.5 mm of the atlas-based predicted values. Our findings provide simple, rapid and precise methods that are of clinical relevance to the atlas-based and direct stereotactic localization of the human PPN. Direct MRI localization may allow greater individual accuracy than that afforded by atlas-based coordinates when localizing the human PPN and may be relevant to groups evaluating the clinical role of PPN DBS.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Zrinzo, Ludvic" sort="Zrinzo, Ludvic" uniqKey="Zrinzo L" first="Ludvic" last="Zrinzo">Ludvic Zrinzo</name></noRegion><name sortKey="Afshar, Farhad" sort="Afshar, Farhad" uniqKey="Afshar F" first="Farhad" last="Afshar">Farhad Afshar</name><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name><name sortKey="Limousin, Patricia Dowsey" sort="Limousin, Patricia Dowsey" uniqKey="Limousin P" first="Patricia Dowsey" last="Limousin">Patricia Dowsey Limousin</name><name sortKey="Tisch, Stephen" sort="Tisch, Stephen" uniqKey="Tisch S" first="Stephen" last="Tisch">Stephen Tisch</name><name sortKey="Yousry, Tarek A" sort="Yousry, Tarek A" uniqKey="Yousry T" first="Tarek A." last="Yousry">Tarek A. Yousry</name><name sortKey="Zrinzo, Laurence V" sort="Zrinzo, Laurence V" uniqKey="Zrinzo L" first="Laurence V." last="Zrinzo">Laurence V. Zrinzo</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Zrinzo, Ludvic" sort="Zrinzo, Ludvic" uniqKey="Zrinzo L" first="Ludvic" last="Zrinzo">Ludvic Zrinzo</name></noRegion><name sortKey="Afshar, Farhad" sort="Afshar, Farhad" uniqKey="Afshar F" first="Farhad" last="Afshar">Farhad Afshar</name><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name><name sortKey="Limousin, Patricia Dowsey" sort="Limousin, Patricia Dowsey" uniqKey="Limousin P" first="Patricia Dowsey" last="Limousin">Patricia Dowsey Limousin</name><name sortKey="Tisch, Stephen" sort="Tisch, Stephen" uniqKey="Tisch S" first="Stephen" last="Tisch">Stephen Tisch</name><name sortKey="Yousry, Tarek A" sort="Yousry, Tarek A" uniqKey="Yousry T" first="Tarek A." last="Yousry">Tarek A. Yousry</name><name sortKey="Zrinzo, Laurence V" sort="Zrinzo, Laurence V" uniqKey="Zrinzo L" first="Laurence V." last="Zrinzo">Laurence V. Zrinzo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B87 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B87 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:464220914CF1D24BAA9D72BF263683114786B324
|texte= Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization
}}
| This area was generated with Dilib version V0.6.23. |  |